L-006235

MedChem Express

L-006235

10

294623-49-7

Research Use Only

99.93

C24H30N6O2S

466.60

L-006235 (L-235) is a potent, selective, reversible and orally active inhibitor of cathepsin K, with an IC50 of 5 nM in bone resorption assay. L-006235 shows selectivity for cathepsin K (Ki=0.2 nM) over cathepsin B, cathepsin L, and cathepsin S (Ki=1, 6, and 47 microM, respectively). L-006235 can reduce collagen degradation and prevent bone loss[1][2].

O=C(NC1(C(NCC#N)=O)CCCCC1)C2=CC=C(C3=CSC(N4CCN(C)CC4)=N3)C=C2

-20°C,2°C to 8°C

12352200