L-006235 (Standard) [294623-49-7]

MedChem Express

L-006235 (Standard) [294623-49-7]

5

294623-49-7

CHEMICAL,detergents_surfactants

Research Use Only

466.60

L-006235 (Standard) is the analytical standard of L-006235. This product is intended for research and analytical applications. L-006235 (L-235) is a potent, selective, reversible and orally active inhibitor of cathepsin K, with an IC50 of 5 nM in bone resorption assay. L-006235 shows selectivity for cathepsin K (Ki=0.2 nM) over cathepsin B, cathepsin L, and cathepsin S (Ki=1, 6, and 47 microM, respectively). L-006235 can reduce collagen degradation and prevent bone loss[1][2].

O=C(NC1(C(NCC#N)=O)CCCCC1)C2=CC=C(C3=CSC(N4CCN(C)CC4)=N3)C=C2

12352005