L-748328 [244192-93-6]

MedChem Express

L-748328 [244192-93-6]

9

244192-93-6

Research Use Only

C23H27N3O6S2

505.61

L-748328 is a potent and selective human beta3-adrenergic receptor antagonist. L-748328 has a Ki of 3.7 nM against human cloned beta3-AR expressed in Chinese hamster ovary (CHO) cells. In addition, L-748328 inhibits the lipolytic response induced by the beta3-AR agonist L-742791 in isolated non-human primate adipocytes[1].

O=S(C1=CC=CC(OC[C@H](CNCCC2=CC=C(C=C2)NS(=O)(C3=CC=CC=C3)=O)O)=C1)(N)=O

12352200