L-764406 [227002-04-2]
HY-121579
CAS Number227002-04-2
Product group Chemicals
Molecular Weight318.78
Overview
- SupplierMedChem Express
- Product NameL-764406 [227002-04-2]
- Delivery Days Customer5
- CAS Number227002-04-2
- CertificationResearch Use Only
- Molecular FormulaC15H11ClN2O2S
- Molecular Weight318.78
- Scientific DescriptionL-764406 is a non-thiazolidinedione (TZD)-type PPARg nuclear receptor ligand with high affinity. L-764406 has significant binding ability to PPARg (IC50=70 nM). L-764406 exhibited partial agonist activity and induced expression of the adipocyte-specific gene aP2 in chimeric receptors expressing the PPARg LBD and the corresponding reporter gene, as well as in 3T3-L1 cells. In contrast, L-764406 showed no activity in cells transfected with chimeric receptors containing PPARa or PPARd LBDs[1].
- SMILESO=S(CC1=NC2=CC=CC=C2N=C1Cl)(C3=CC=CC=C3)=O
- UNSPSC12352200