L-778123 Dihydrochloride [183499-56-1]

TargetMol Chemicals

L-778123 Dihydrochloride [183499-56-1]

72

Research Use Only

L-778123 Dihydrochloride

C22H22Cl3N5O

478.802

L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.

3 years

Cl.Cl.Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O

-20°C

12352200