L-838417 [286456-42-6]

MedChem Express

L-838417 [286456-42-6]

5

286456-42-6

Research Use Only

99.22

C19H19F2N7O

399.41

L-838417 is a selective partial agonist at the alpha2, alpha3 and alpha5 subtypes of the GABAA receptor and an antagonist at the alpha1, with binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for alpha1beta3gamma2, alpha2beta3gamma2, alpha3beta3gamma2, alpha4beta3gamma2, alpha5beta3gamma2 and alpha6beta3gamma2[1].

CN1N=CN=C1COC2=NN3C(C=C2C(C)(C)C)=NN=C3C4=CC(F)=CC=C4F

-20°C

12352200