L-Asparagine-15N2 (monohydrate) [287484-32-6]

MedChem Express

L-Asparagine-15N2 (monohydrate) [287484-32-6]

10

287484-32-6

Research Use Only

98.0

C4H10 15N2O4

152.12

L-Asparagine-15N2 monohydrate is the 15N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5][6].

[15NH2]C(C[C@H]([15NH2])C(O)=O)=O.[H]O[H]

2°C to 8°C

12352200