L-Asparagine

MedChem Express

L-Asparagine [70-47-3]

10

70-47-3

Research Use Only

98.0

C4H8N2O3

132.12

L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5].

N[C@H](C(O)=O)CC(N)=O

-20°C,2°C to 8°C

12352200