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L-Homopropargylglycine (L-HPG) [942518-19-6]

Research Use Only
CLK-1067-25
Jena Bioscience
CAS Number942518-19-6
Product group Chemicals
Molecular Weight163.60 g/mol (HCl salt)
€ 221,00
25 mg
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Overview

  • Supplier
    Jena Bioscience
  • Product Name
    L-Homopropargylglycine (L-HPG) [942518-19-6]
  • Delivery Days Customer
    5
  • CAS Number
    942518-19-6
  • Certification
    Research Use Only
  • Molecular Formula
    C6H9NO2 * HCl
  • Molecular Weight
    163.60 g/mol (HCl salt)
  • Scientific Description
    L-Homopropargylglycine (L-HPG) provides a non-radioactive alternative to analyze the global protein synthesis in cell culture. It is cell-permeable and randomly incorporated instead of methionine during translation[1,2,3]. The resulting alkyne-labeled full-length proteins can subsequently be detected via Cu(I)-catalyzed click chemistry that offers the choice to introduce a Biotin group (via Azides of Biotin) for subsequent purification tasks or a fluorescent group (via Azides of fluorescent dyes) for subsequent microscopic imaging. Presolski et al.[4] and Hong et al.[5] provide a general protocol for Cu(I)-catalyzed click chemistry reactions that may be used as a starting point for the set up and optimization of individual assays.
  • SMILES
    [C@@H](C(=O)O)(CCC#C)N.Cl
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200