L67

MedChem Express

L67 [325970-71-6]

10

325970-71-6

Research Use Only

98.0

C16H14Br2N4O4

486.11

L67 (DNA Ligase Inhibitor) is a competitive DNA ligase inhibitor that effectively inhibits DNA ligases I/III (both IC 50 are 10 microM). L67 can cause nuclear DNA damage by reducing levels of mitochondrial DNA and increasing levels of mitochondrially-generated ROS. L67 also activates the Caspase 1 -dependent apoptosis pathway in cancer cells, can be used in cancer research [1] [2] .

BrC1=CC(NCC(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)=CC(Br)=C1C

-20°C,2°C to 8°C

12352200