L6H21 [24533-47-9]
HY-W082785A
CAS Number24533-47-9
Product group Chemicals
Estimated Purity99.19
Molecular Weight298.34
Overview
- SupplierMedChem Express
- Product NameL6H21 [24533-47-9]
- Delivery Days Customer10
- CAS Number24533-47-9
- CertificationResearch Use Only
- Estimated Purity99.19
- Molecular FormulaC18H18O4
- Molecular Weight298.34
- Scientific DescriptionL6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low KD value of 33.3 microM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-alpha and IL-6 in RAW264.7 macrophages, with IC50 values of 6.58 and 8.59 microM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research[1][2][3].
- SMILESO=C(C1=CC=C(OC)C=C1)/C=C/C2=CC=CC(OC)=C2OC
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200