L748337

MedChem Express

L748337 [244192-94-7]

10

244192-94-7

Research Use Only

99.0

C26H31N3O5S

497.61

L748337 is a potent beta3-adrenergic receptor antagonist and displays selectivity over beta1 and beta2 receptors. The Ki values of L748337 for beta3-, beta2- and beta1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively[1]. L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6[2]. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases[1][2][3].

CC(NCC1=CC=CC(OC[C@@H](O)CNCCC2=CC=C(NS(=O)(C3=CC=CC=C3)=O)C=C2)=C1)=O

-20°C

12352200