L748337

MedChem Express

L748337 [244192-94-7]

10

244192-94-7

Research Use Only

99.67

C26H31N3O5S

497.61

L748337 is a potent beta3-adrenergic receptor antagonist and displays selectivity over?beta1?and?beta2?receptors. The K i values of L748337 for beta3-,?beta2- and?beta1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively [1] . L748337 couples predominantly to G i to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC 50 value of 11.6 [2] . L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases [1] [2] [3] .

CC(NCC1=CC=CC(OC[C@@H](O)CNCCC2=CC=C(NS(=O)(C3=CC=CC=C3)=O)C=C2)=C1)=O

-20°C

12352200