L755,507, CRISPR Editing Enhancer

Bioss

L755,507, CRISPR Editing Enhancer

16

Research Use Only

L-755, 507 was previously characterized as a potent and selective beta3 adrenergic receptor partial agonist with EC50 ~0.43 nM. It has > 1000 fold selectivity overbeta1- and beta2-adrenoceptors (EC50 ~ 580 nM and >10000 nM forbeta1- and beta2-adrenoceptors respectively). It stimulates lipolysis in rhesus adipocytes in vitro (EC50 = 3.9 nM). In a recent study, L-755, 507 was identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.

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