Lactandrate [43000-65-3]

MedChem Express

Lactandrate [43000-65-3]

9

43000-65-3

Research Use Only

C31H44Cl2N2O3

563.60

Lactandrate is a D-high nitrogen steroid alkylating agent. It can interact with the ligand-binding domain (LBD) of estrogen receptor-alpha (ERalpha). Lactandrate has a growth inhibitory effect on breast cancer cells, with a GI50 value ranging from 5 to 65 microM. It shows anti-tumor activity in mouse breast tumors (MXT and CD8F1) as well as in human xenograft MX-1[1].

C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)OC(CC4=CC=C(C=C4)N(CCCl)CCCl)=O)([H])[C@@]5([H])[C@](CC3)(NC(CC5)=O)C

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