Lactoferrin, Neutrophil [146897-68-9]

Athens Research

Lactoferrin, Neutrophil [146897-68-9]

9

Iron Transport, Antimicrobial, Inflammation, Immunology, Infection

146897-68-9

Research Use Only

≥95% by SDS-PAGE

Lactotransferrin

Neutrophil lactoferrin is a multifunctional glycoprotein stored in the secondary granules of polymorphonuclear neutrophils and released during immune responses. In addition to its presence in exocrine secretions such as saliva, tears, and milk, neutrophil-derived lactoferrin plays a pivotal role in the body’s innate defense mechanisms. Upon release, it binds free iron with high affinity, limiting iron availability to invading bacteria and thereby exerting potent bacteriostatic and bactericidal effects. This iron-sequestration not only inhibits microbial growth but also helps modulate inflammatory responses at sites of infection. Furthermore, neutrophil lactoferrin regulates intestinal iron absorption, contributing to iron homeostasis and preventing iron overload or deficiency. Clinically, altered levels of neutrophil lactoferrin have been associated with inflammatory diseases, infections, and certain autoimmune conditions. Its antimicrobial and immunomodulatory properties make it a promising candidate for therapeutic applications in treating infections, inflammatory disorders, and supporting immune health.

more then 1 year

Neutrophils shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

≤ -80°C

12352202