Laduviglusib

MedChem Express

Laduviglusib [252917-06-9]

10

252917-06-9

Research Use Only

99.76

C22H18Cl2N8

465.34

Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3alpha/beta inhibitor with IC 50 s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/beta-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy [1] [2] [3] .

N#CC1=CC=C(N=C1)NCCNC2=NC=C(C(C3=CC=C(Cl)C=C3Cl)=N2)C4=NC=C(N4)C

-20°C,2°C to 8°C

12352200