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Laduviglusib

Research Use Only
HY-10182
MedChem Express
CAS Number252917-06-9
Product group Chemicals
Estimated Purity99.76
Molecular Weight465.34
Price on request
Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Laduviglusib [252917-06-9]
  • Delivery Days Customer
    10
  • CAS Number
    252917-06-9
  • Certification
    Research Use Only
  • Estimated Purity
    99.76
  • Molecular Formula
    C22H18Cl2N8
  • Molecular Weight
    465.34
  • Scientific Description
    Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3alpha/beta inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/beta-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy[1][2][3].
  • SMILES
    N#CC1=CC=C(N=C1)NCCNC2=NC=C(C(C3=CC=C(Cl)C=C3Cl)=N2)C4=NC=C(N4)C
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200