Laflunimus

MedChem Express

Laflunimus [147076-36-6]

9

147076-36-6

Research Use Only

99.76

C15H13F3N2O2

310.27

Laflunimus (HR325) is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726. Laflunimus is an orally active inhibitor of dihydroorotate dehydrogenase (DHODH) . Laflunimus suppresses immunoglobulin (Ig) secretion, with IC 50 values of 2.5 and 2 microM for IgM and IgG, respectively. Laflunimus also is a prostaglandin endoperoxide H synthase (PGHS) -1 and -2 inhibitor [1] [2] .

O=C(NC1=CC=C(C(F)(F)F)C(C)=C1)/C(C#N)=C(C2CC2)\O

-20°C,2°C to 8°C

12352200