LAMTOR5 Antibody

Cusabio

LAMTOR5 Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

LAMTOR5

late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

HBXIP, XIP, ragulator complex protein LAMTOR5, HBV X-interacting protein, HBx-interacting protein, hepatitis B virus x interacting protein, hepatitis B virus x-interacting protein (9.6kD), late endosomal/lysosomal adaptor and MAPK and MTOR activator 5

Rabbit

IgG

Ragulator complex protein LAMTOR5

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Human

-20°C or -80°C

41116161