Landiolol (hydrochloride)
HY-100607A
Overview
- SupplierMedChem Express
- Product NameLandiolol (hydrochloride) [144481-98-1]
- Delivery Days Customer10
- CAS Number144481-98-1
- CertificationResearch Use Only
- Estimated Purity99.96
- Molecular FormulaC25H40ClN3O8
- Molecular Weight546.05
- Scientific DescriptionLandiolol (ONO1101) hydrochloride is a highly selective, ultra-short-acting competitive inhibitor of beta1 adrenergic receptors. Landiolol hydrochloride specifically blocks cardiac beta1 receptors, reducing heart rate and myocardial oxygen consumption. Landiolol hydrochloride inhibits TNF-alpha-induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol hydrochloride has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current) and has a weak negative inotropic effect. Landiolol hydrochloride can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury[1][2][3].
- SMILESO=C(OC[C@H]1OC(C)(C)OC1)CCC2=CC=C(OC[C@@H](O)CNCCNC(N3CCOCC3)=O)C=C2.[H]Cl
- Storage Instruction2°C to 8°C
- UNSPSC12352200