IHC-P analysis of human skin tissue using GTX01915 Langerin antibody [12D6].
IHC-P analysis of human skin tissue using GTX01915 Langerin antibody [12D6].
Langerin antibody [12D6]
GTX01915
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetCD207
Overview
- SupplierGeneTex
- Product NameLangerin antibody [12D6]
- Delivery Days Customer9
- Application Supplier NoteIHC-P: 1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID12D6
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID50489
- Target nameCD207
- Target descriptionCD207 molecule
- Target synonymsCD207 antigen, langerin; CD207 molecule, langerin; CLEC4K; C-type lectin domain family 4 member K; C-type lectin domain family 4, member K; Langerhans cell specific c-type lectin
- HostMouse
- IsotypeIgG2b
- Protein IDQ9UJ71
- Protein NameC-type lectin domain family 4 member K
- Scientific DescriptionThe protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Langerhans cell histiocytosis of an intra-mammary lymph node in an 18-year-old woman. Ungari M et al., 2020 Mar, PathologicaRead more
- Different methods of cell quantification can lead to different results: a comparison of digital methods using a pilot study of dendritic cells in HIV-positive patients. Fernandes DT et al., 2020 May 1, Med Oral Patol Oral Cir BucalRead more
- Desmoplastic melanoma involving head and fingers: diagnostic challenges and clinical characteristics. Yang Y et al., 2019, Int J Clin Exp PatholRead more
- ALK-positive histiocytosis: an expanded clinicopathologic spectrum and frequent presence of KIF5B-ALK fusion. Chang KTE et al., 2019 May, Mod PatholRead more
- Langerin staining identifies most littoral cell angiomas but not most other splenic angiomatous lesions. Selove W et al., 2019 Jan, Hum PatholRead more