Langerin antibody [12D6]

Name: Langerin antibody [12D6]
SKU: GTX01915_G10
Availability: BackOrder

GTX01915

ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman

TargetCD207

Overview

Supplier
GeneTex
Product Name
Langerin antibody [12D6]
Delivery Days Customer
9
Application Supplier Note
IHC-P: 1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
12D6
Conjugate
Unconjugated
Gene ID50489
Target name
CD207
Target description
CD207 molecule
Target synonyms
CLEC4K, C-type lectin domain family 4 member K, C-type lectin domain family 4, member K, CD207 antigen, langerin, CD207 molecule, langerin, Langerhans cell specific c-type lectin
Host
Mouse
Isotype
IgG2b
Protein IDQ9UJ71
Protein Name
C-type lectin domain family 4 member K
Scientific Description
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]
Reactivity
Human
Storage Instruction
2°C to 8°C
UNSPSC
12352203

Ungari M, Ferrero G, Varotti E, et al. Langerhans cell histiocytosis of an intra-mammary lymph node in an 18-year-old woman. Pathologica. 2020,112(1):50-55. doi: 10.32074/1591-951X-27-19
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Fernandes DT, van Heerden WF, Ribeiro AC, et al. Different methods of cell quantification can lead to different results: a comparison of digital methods using a pilot study of dendritic cells in HIV-positive patients. Med Oral Patol Oral Cir Bucal. 2020,25(3):e431-e438. doi: 10.4317/medoral.23472
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Yang Y, Yang F, Zhu Y, et al. Desmoplastic melanoma involving head and fingers: diagnostic challenges and clinical characteristics. Int J Clin Exp Pathol. 2019,12(10):3862-3869.
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Chang KTE, Tay AZE, Kuick CH, et al. ALK-positive histiocytosis: an expanded clinicopathologic spectrum and frequent presence of KIF5B-ALK fusion. Mod Pathol. 2019,32(5):598-608. doi: 10.1038/s41379-018-0168-6
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Selove W, Picarsic J, Swerdlow SH. Langerin staining identifies most littoral cell angiomas but not most other splenic angiomatous lesions. Hum Pathol. 2019,83:43-49. doi: 10.1016/j.humpath.2018.08.012
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