Langerin antibody [12D6]

GeneTex

Langerin antibody [12D6]

9

IHC-P: 1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

12D6

Unconjugated

CD207

CD207 molecule

CLEC4K, C-type lectin domain family 4 member K, C-type lectin domain family 4, member K, CD207 antigen, langerin, CD207 molecule, langerin, Langerhans cell specific c-type lectin

Mouse

IgG2b

C-type lectin domain family 4 member K

The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]

Human

2°C to 8°C

41116161