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LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated

LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated

TMPJ-00250
TargetMol Chemicals
DownloadMSDS
Product group Proteins / Signaling Molecules
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
  • Delivery Days Customer
    16
  • Certification
    Research Use Only
  • Scientific Description
    Transforming growth factor beta (TGFbeta) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGFbeta gene product. Extracellular activation of these complexes is a critical step in regulation of TGFbeta function in vivo. The TGFbeta1 LAP is a ligand for the integrin alphavbeta6 and that alphavbeta6-expressing cells induce spatially restricted activition of TGFbeta1. And LAP identifies a novel CD4+/CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352202

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