Lasmiditan HCl

Biorbyt

Lasmiditan HCl

10

Research Use Only

C19H19CLF3N3O2

413.821274

Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 microM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study. Lasmiditan showed efficacy in its primary endpoint, with a 2-hour placebo-subtracted headache response of 28.8%, though with frequent reports of dizziness, paresthesias, and vertigo.

O=C(C1C(F)=CC(F)=CC=1F)NC1C=CC=C(C(=O)C2CCN(C)CC2)N=1.[H]Cl

12352200