LAT (C2) Antibody, Rabbit Polyclonal

Biorbyt

LAT antibody

16

Western Blot

WB:1:1000-1:3000 WB

Research Use Only

Polyclonal

Unconjugated

Lat

linker for activation of T cells

36 kDa phospho-tyrosine adapter protein; linker for activation of T-cells family member 1; linker protein; p36-38; pp36

Rabbit

Linker for activation of T-cells family member 1

Rabbit polyclonal to LAT.Linker for activation of T-cells family member 1 (LAT) is a single-pass type III cell membrane protein.LAT is required for TCR (T-cell antigen receptor)-and pre-TCR-mediated signaling, both in mature Tcellsand during their development. LAT is involved in FCGR3 (low affinity immunoglobulin gamma Fcregion receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulinepsilon receptor)-mediated signaling in mast cells. LAT couples activation of these receptors and theirassociated kinases with distal intracellular events, such as mobilization of intracellular calcium stores,PKC activation, MAPK activation or cytoskeletal reorganization through the recruient of PLCG1,GRB2, GRAP2 and other signaling molecules.

-20°C

12352203