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WB analysis of Jurkat E6.1 cells were left unstimulated (1) or stimulated (2-5) using GTX24476 LAT (phospho Tyr132) antibody.
WB analysis of Jurkat E6.1 cells were left unstimulated (1) or stimulated (2-5) using GTX24476 LAT (phospho Tyr132) antibody.
WB analysis of Jurkat E6.1 cells were left unstimulated (1) or stimulated (2-5) using GTX24476 LAT (phospho Tyr132) antibody.

LAT (phospho Tyr132) antibody

GTX24476
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetLAT
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Overview

  • Supplier
    GeneTex
  • Product Name
    LAT (phospho Tyr132) antibody - Orthogonal Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 0.1-1 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID27040
  • Target name
    LAT
  • Target description
    linker for activation of T cells
  • Target synonyms
    36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; IMD52; LAT1; linker for activation of T cells, transmembrane adaptor; linker for activation of T-cells family member 1; p36-38; pp36
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO43561
  • Protein Name
    Linker for activation of T-cells family member 1
  • Scientific Description
    The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-gamma1 Activation and Cytokine Production. Bilal MY et al., 2015, Front Immunol
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  • Novel CD3-specific antibody induces immunosuppression via impaired phosphorylation of LAT and PLCgamma1 following T-cell stimulation. Shiheido H et al., 2014 Jun, Eur J Immunol
    Read more