LC-MB12
HY-149843
Overview
- SupplierMedChem Express
- Product NameLC-MB12 [2828438-38-4]
- Delivery Days Customer14
- CertificationResearch Use Only
- Estimated Purity99.23
- Molecular FormulaC43H44Cl2N10O8
- Molecular Weight899.78
- Scientific DescriptionLC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11.8 nM. LC-MB12 contains BGJ398 (a FGFR2 inhibitor), PROTAC linker and CRBN.LC-MB12 inhibits FGFR2 signaling in gastric cancer cells and has anti-tumor activity[1].
- SMILESO=C(N(C)C1=CC(NC2=CC=C(N3CCN(CC3)C(C4CCN(CC4)C5=CC=C6C(N(C7C(NC(CC7)=O)=O)C(C6=C5)=O)=O)=O)C=C2)=NC=N1)NC8=C(Cl)C(OC)=CC(OC)=C8Cl
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12131703