LCC-12 (formate)

MedChem Express

LCC-12 (formate)

999

Research Use Only

C17H38N10O2

414.55

LCC-12 (formate) is a copper (II) chelator and a derivative of the biguanide metformin (HY-B0627). LCC-12 (formate) reduces its hydrogen peroxide-dependent oxidation of NADH to NAD+. LCC-12 (formate) reduces IL-1beta, IL-2, IL-6, IL-8, and TNF-alpha levels, as well as JAK2, STAT2, and IL-1 receptor-associated kinase 4 (IRAK4) levels in primary human cytokine-activated monocyte-derived macrophages (MDMs). LCC-12 (formate) reduces the number of CD80+ and CD86+ cytokine-activated MDMs. LCC-12 LCC-12 (formate) improves survival in a mouse model of sepsis induced by LPS or cecal ligation and puncture[1].

NC(NC(NCCCCCCCCCCCCNC(NC(N)=N)=N)=N)=N.O=CO

12352200