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ProductsBack/LDC195943 (IMT1)

LDC195943 (IMT1)

E0443

Estimated Purity...

Product group Chemicals

Overview

Supplier
Selleck Chemicals
Product Name
LDC195943 (IMT1)
Delivery Days Customer
9
Certification
Research Use Only
Estimated Purity
...
Scientific Description
LDC195943 (IMT1) is a specific and noncompetitive inhibitor of human mitochondrial RNA polymerase (POLRMT). IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.
UNSPSC
51202000

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