LDN-57444 --- Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) Inhibitor
BS-60204C
Estimated Purity98.0
Product group Chemicals
Overview
- SupplierBioss
- Product NameLDN-57444 --- Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) Inhibitor
- Delivery Days Customer16
- CertificationResearch Use Only
- Estimated Purity98.0
- Scientific DescriptionLDN-57444 is a novel potent and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) with IC50 ~0.88 microM. It has ~28-fold greater selectivity over UCH-L3 (ubiquitin C-terminal hydrolase L3). LDN-57444 can increase levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. It causes cell death through the apoptosis pathway. LDN-57444s activity leads to dramatic alterations in synaptic protein distribution and spine morphology in vivo.
- Storage Instruction-20°C
- UNSPSC51202000