LE 300 [274694-98-3]

MedChem Express

LE 300 [274694-98-3]

5

274694-98-3

Research Use Only

98.5

C20H22N2

290.40

LE 300 is a potent and selective dopamine D1-like receptor antagonist with Kis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. LE 300 is an antagonist of the 5-HT2A receptor with a pA2 of 8.32 in a rat tail artery assay[1][2].

CN1CCC2=C(NC3=C2C=CC=C3)CC4=CC=CC=C4CC1

-20°C

12352200