LEFTY2 antibody [5A25]

GeneTex

LEFTY2 antibody [5A25]

9

WB: 1:500 - 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Monoclonal

5A25

500 ug/ml

Unconjugated

LEFTY2

left-right determination factor 2

EBAF, LEFTA, LEFTYA, TGFB4, left-right determination factor 2, TGF-beta-4, endometrial bleeding-associated factor, left-right determination factor A, protein lefty-2, protein lefty-A, transforming growth factor beta-4

Mouse

IgG2

Left-right determination factor 2

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]

-20°C or -80°C,2°C to 8°C

12352203