LEK 8841 (methanesulfonate) [145204-80-4]

MedChem Express

LEK 8841 (methanesulfonate) [145204-80-4]

9

145204-80-4

Research Use Only

C21H24BrN3O4S

494.40

LEK 8841 methanesulfonate is a gastrointestinal calming agent with strong selective 5-HT2 receptor antagonist activity. The antipsychotic potential of LEK 8841 has made it the focus of research into alternative medicines. LEK 8841 behaves as a pure competitive antagonist in response to 5-HT and norepinephrine, with pA2 values of 7.93 and 6.45, respectively. The selectivity of LEK 8841 is better than that of the comparative drug ketanserin, making it an important reference value in corresponding receptor research. Studies related to structural modifications have shown that LEK 8841 exhibits high affinity for 5-HT2 receptors and low alpha-adrenergic receptor activity[1].

BrC1=C2C3=C(C4=C[C@@H](C(N(C)CC#C)=O)CN(C)[C@]4([H])C2)C=CC=C3N1.CS(=O)(O)=O

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