Lenalidomide 4-alkyl-C3-azide [2399455-71-9]

TargetMol Chemicals

Lenalidomide 4-alkyl-C3-azide [2399455-71-9]

999

Chemical

Research Use Only

Lenalidomide 4'-alkyl-C3-azide

C16H18N6O3

342.35

Lenalidomide 4-alkyl-C3-azide (compound 4a), a chemically modified version of the orally active immunomodulator lenalidomide, is engineered for the synthesis of PROTACs. This compound, serving as a ligand for the ubiquitin E3 ligase cereblon (CRBN), integrates an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups [1].

3 years

N(CCCN=[N+]=[N-])C1=C2C(C(=O)N(C2)C3C(=O)NC(=O)CC3)=CC=C1

-20°C

12352200