Leptin (mouse, rat) ELISA kit

PRODUCT EXPLANATION: LEPTIN|Gruver AL., Sempowski GD. Cytokines, leptin, and stress-induced thymic atrophy. J Leukoc Biol. (2008) May|Cherhab FF., Mounzih K., Lu R. et al. Early onset of reproductive function in normal mice treated with Leptin. Science 275, 88 (1997)|Clement K., Vaisse C., Lahlou . et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 329, 398 (1998)|Considine R.V., Sinha M.K., Heiman M.L. et al. Serum immunoreactive leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334, 292-295 (1996)|Friedman JM., Halaas JL. Leptin and regulation of body weight in mammals. Nature 395, 763 (1998)|Halaas J.L., Gajiwala K.S., Maffei M.. et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543-546 (1995)|Montague CT., Faroozi IS., Witehead JP. et al. Congenital leptin defi ciency defi ciency is associated with serve early-onset obesity in humans. Nature 387, 903 (1997)|Pelleymounter M.A., Cullen M.J., Baker M.B. et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540-543 (1995)|Zhang Y., Proenca R., Maffei M.. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432 (1994)|PRODUCT EXPLANATION: KIT DEVELOPMENT|Valentin MA, Ma S, Zhao A, Legay F, Avrameas A. Validation of immunoassay for protein biomarkers: Bioanalytical study plan implementation to support pre-clinical and clinical studies. J Pharm Biomed Anal. (2011) 55(5): 869-877|European Medicines Agency. Guideline on bioanalytical method validation, 21 July 2011|CITATIONS OF SPI-BIO LEPTIN KIT|Mashmoul M, Azlan A, Mohtarrudin N et al, Saffron Extract and Crocin Reduced Biomarkers Associated with Obesity in Rats Fed a High-Fat Diet. Mal J Nutr 23(1) : 117 - 127, 2017|Noaman I.M, The Effect of Serotonin on Leptin and Grelin Hormones Concentrations in Female Rats. Kufa Journal For Veterinary Medical Sciences Vol. (6) No. (2) 2015|Hoile SP, Grenfell LM, Hanson MA et al, Fat and carbohydrate intake over three generations modify growth, metabolism and cardiovascular phenotype in female mice in an age-related manner. PLoS One. 2015 Aug 12 ;10(8) : e0134664|Lefils J, Géloën A, Vidal H et al, Dietary DHA : time course of tissue uptake and effects on cytokine secretion in mice. Br J Nutr. 2010 Nov ;104(9) :1304-12|Aminzadeh MA, Pahl MV, Barton CH et al, Human uraemic plasma stimulates release of leptin and uptake of tumour necrosis factor-alpha in visceral adipocytes. Nephrol Dial Transplant. 2009 Dec ;24(12) :3626-31|Pye KM1, Wakefield AP, Aukema HM et al, A high mixed protein diet reduces body fat without altering the mechanical properties of bone in female rats. J Nutr. 2009 Nov ;139(11) :2099-105|Terao S, Yilmaz G, Stokes KY et al, Inflammatory and injury responses to ischemic stroke in obese mice. Stroke. 2008 Mar ;39(3) :943-50