Leriglitazone hydrochloride

Biorbyt

Leriglitazone hydrochloride

10

146062-46-6

Research Use Only

98.00%

C19H21ClN2O4S

408.9

Leriglitazone (Hydroxypioglitazone) hydrochloride, a pioglitazone metabolite, acts as a PPARgamma agonist, effectively stabilizing the PPARgamma activation function-2 (AF-2) co-activator binding surface to enhance co-activator binding, which results in a modest improvement in transcriptional efficacy. It binds to the PPARgamma C-terminal ligand-binding domain (LBD) with a dissociation constant (K i) of 1.2 microM and demonstrates transcriptional efficacy with an effective concentration (EC 50) of 680 nM [1].

Cl.CC(O)c1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1

-20°C

12352200