Leucettine L41 [1112978-84-3]

MedChem Express

Leucettine L41 [1112978-84-3]

10

1112978-84-3

Research Use Only

98.98

C17H13N3O3

307.30

Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 microM, respectively)[1]. Leucettine L41 prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by Abeta25-35 in the hippocampus in a mouse model of Alzheimers disease-like toxicity. Leucettine L41 also prevents memory deficits induced by Abeta25-35 in the same model[2].

O=C1NC(NC2=CC=CC=C2)=N/C1=C\C3=CC=C(OCO4)C4=C3

-20°C,2°C to 8°C

12352200