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Chemical Structure
Chemical Structure
Chemical Structure

Leucettinib-21

Research Use Only
AG-MR-C0047
AdipoGen Life Sciences
Product group Chemicals
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Leucettinib-21
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Scientific Description
    Chemical. CAS: 2732859-75-3. Formula: C18H22N4O2S. MW: 358.5. Soluble in DMSO (10mM) or ethanol. Potent inhibitor of DYRK1A (IC50=2.4nM), DYRK1B (IC50=6.7nM), CLK1 (IC50=11.8nM) and CLK4 (IC50=5nM) kinases [2]. Inhibits the phosphorylation of Tau at Thr212 and cyclin D1 at Thr286, native DYRK1A in HT-22 cells and triggers cell apoptotic cell death. Corrects cognitive deficits in Ts65Dn model of Down syndrome and other models. iso-Leucettinib-21 (Prod. No. AG-MR-C0048) is a kinase-inactive isomer and should be used as a negative control together with this compound. - Potent inhibitor of DYRK1A (IC50=2.4nM), DYRK1B (IC50=6.7nM), CLK1 (IC50=11.8nM) and CLK4 (IC50=5nM) kinases [2]. Inhibits the phosphorylation of Tau at Thr212 and cyclin D1 at Thr286, native DYRK1A in HT-22 cells and triggers cell apoptotic cell death. Corrects cognitive deficits in Ts65Dn model of Down syndrome and other models. iso-Leucettinib-21 (Prod. No. AG-MR-C0048) is a kinase-inactive isomer and should be used as a negative control together with this compound.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200