Chemical Structure
Chemical Structure
Leucettinib-92 [2732859-57-1]
AG-MR-C0049
CAS Number2732859-57-1
Product group Chemicals
Estimated Purity>99%
Molecular Weight378.5
Overview
- SupplierAdipoGen Life Sciences
- Product NameLeucettinib-92 [2732859-57-1]
- Delivery Days Customer10
- CAS Number2732859-57-1
- CertificationResearch Use Only
- Estimated Purity>99%
- Hazard InformationWarning
- Molecular FormulaC21H22N4OS
- Molecular Weight378.5
- Scientific DescriptionChemical. CAS: 2732859-57-1. Formula: C21H22N4OS. MW: 378.5. Soluble in DMSO (10mM) or ethanol. Potent inhibitor of DYRK1A (IC50=1.2nM), DYRK1B (IC50=1.8nM), DYRK3 (IC50=19.3nM) and CLK2 (IC50=0.6nM) [1]. Inhibits the phosphorylation of Tau at Thr212 and cyclin D1 at Thr286. Corrects cognitive deficits in animal models of Down syndrome. iso-Leucettinib-92 (Prod. No. AG-MR-C0050) is a kinase-inactive isomer and should be used as a negative control together with this compound. - Potent inhibitor of DYRK1A (IC50=1.2nM), DYRK1B (IC50=1.8nM), DYRK3 (IC50=19.3nM) and CLK2 (IC50=0.6nM) [1]. Inhibits the phosphorylation of Tau at Thr212 and cyclin D1 at Thr286. Corrects cognitive deficits in animal models of Down syndrome. iso-Leucettinib-92 (Prod. No. AG-MR-C0050) is a kinase-inactive isomer and should be used as a negative control together with this compound.
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12161509