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Chemical Structure
Chemical Structure
Chemical Structure

Leucettinib-92

Research Use Only
AG-MR-C0049
AdipoGen Life Sciences
Product group Chemicals
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Leucettinib-92
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Scientific Description
    Chemical. CAS: 2732859-57-1. Formula: C21H22N4OS. MW: 378.5. Soluble in DMSO (10mM) or ethanol. Potent inhibitor of DYRK1A (IC50=1.2nM), DYRK1B (IC50=1.8nM), DYRK3 (IC50=19.3nM) and CLK2 (IC50=0.6nM) [1]. Inhibits the phosphorylation of Tau at Thr212 and cyclin D1 at Thr286. Corrects cognitive deficits in animal models of Down syndrome. iso-Leucettinib-92 (Prod. No. AG-MR-C0050) is a kinase-inactive isomer and should be used as a negative control together with this compound. - Potent inhibitor of DYRK1A (IC50=1.2nM), DYRK1B (IC50=1.8nM), DYRK3 (IC50=19.3nM) and CLK2 (IC50=0.6nM) [1]. Inhibits the phosphorylation of Tau at Thr212 and cyclin D1 at Thr286. Corrects cognitive deficits in animal models of Down syndrome. iso-Leucettinib-92 (Prod. No. AG-MR-C0050) is a kinase-inactive isomer and should be used as a negative control together with this compound.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200