LeuRS-IN-2

MedChem Express

LeuRS-IN-2

5

Research Use Only

C19H24BBrN2O3

419.12

LeuRS-IN-2 (Compound 9) is a Wolbachia leucyl-tRNA synthetase (LeuRS) inhibitor in the presence of adenosine monophosphate (AMP) with an EC50 value of 6 nM, efficiently arresting the growth of pathogenic host. LeuRS-IN-2 forms adenosine-based adducts inhibiting protein synthesis, which is promising for research of new antimicrobials with disrupting microbiota[1].

CN(CCCOC1=CC=C(Br)C2=C1B(O)O[C@@H]2CN)CC3=CC=CC=C3

12352200