Levistolide A [88182-33-6]

MedChem Express

Levistolide A [88182-33-6]

9

88182-33-6

Research Use Only

99.34

C24H28O4

380.48

Levistolide A is an apoptosis inducer and a PEDV virus inhibitor. Levistolide A can induce apoptosis in colon cancer cells and suppress the replication of porcine epidemic diarrhea virus (PEDV) by promoting ROS generation. Levistolide A activates peroxisome proliferator-activated receptor gamma (PPARgamma) in N2a/APP695swe cells and reduces excessive phosphorylation of tau through the GSK3alpha/beta pathway, improving symptoms in Alzheimers mice. Levistolide A improves kidney damage in 5/6 nephrectomy (Nx) mice by inhibiting the RAS,TGF-beta1/Smad, and MAPK pathways[1][2][3][4].

O=C(O/C([C@@]1(CC2)[C@]34[H])=C\CCC)C1=C[C@]2([H])[C@]3([H])CCC5=C4C(O/C5=C\CCC)=O

-20°C,2°C to 8°C

12352200