LFS-829 [1799330-89-4]

TargetMol Chemicals

LFS-829 [1799330-89-4]

72

Research Use Only

LFS-829

C13H9F6NOS2

373.34

LFS-829 is a a small-molecule antagonist of exportin-1. LFS-829 showed low-range nanomolar activities. Oral administration of LFS-829 can significantly reverse the pathological features of colitis model mice. LFS-829 can attenuate dual NF-kappaB signaling and the Nrf2 cytoprotection pathway via targeting exportin-1 in colitis mice. Moreover, LFS-829 has a very low risk of cardiotoxicity and acute toxicity. LFS-829 holds great promise for the treatment of colitis and may warrant translation for use in clinical trials.

3 years

S(C=CCCN=C=S)(=O)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1

-20°C

12352200