LIB3S0280

MedChem Express

LIB3S0280

10

CHEMICAL,general_chemicals_reagents

Research Use Only

C22H25ClN4O5

460.91

LIB3S0280 is a potent TBK1 inhibitor with an IC50 value of 493.9 nM. LIB3S0280 can inhibit TBK1 downstream signaling by decreasing the phosphorylation of IkappaBalpha and AKT. LIB3S0280 leads to G2/M arrest and induces apoptosis in pancreatic cancer cells. LIB3S0280 shows significant inhibition against pancreatic cancer cell lines that highly express TBK1 with IC50 values of 6.64-10.98 microM at 96 h. LIB3S0280 has the potential for pancreatic ductal adenocarcinoma (PDAC) research[1].

OC1=C(OC)C=C(CCNC2=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=NC=C2Cl)C=C1

-20°C, 3 years (Powder)

12352005