LIGHT/TNFSF14, Human (HEK293, Fc)

MedChem Express

LIGHT/TNFSF14, Human (HEK293, Fc)

10

Research Use Only

91.00

TNFSF14

TNF superfamily member 14

CD258, HVEML, LIGHT, LTg, tumor necrosis factor ligand superfamily member 14, herpesvirus entry mediator ligand, tumor necrosis factor (ligand) superfamily, member 14, tumor necrosis factor ligand 1D, tumor necrosis factor superfamily member 14

Tumor necrosis factor ligand superfamily member 14

LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type [1]. LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNgamma, triggering tumor apoptosis signal [2]. LIGHT/TNFSF14 is also involved in the dominant LTbetaR-NIK-p52 NF-kappaB pathway promoting the expression of inflammatory gene[3]. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection[4]. Human LIGHT/TNFSF14 Protein has 240 amino acids and a transmembrane domain (38-58 a.a.). LIGHT/TNFSF14 Protein, Human (HEK293, Fc) is the extracellular part (D74-V240) of human LIGHT/TNFSF14 Protein, produced by HEK293 cells, with a N-terminal hFc-tag.

-20°C

41116100