LIGHT/TNFSF14, Mouse (sf9, His, solution)

MedChem Express

LIGHT/TNFSF14, Mouse (sf9, His, solution)

10

Research Use Only

98.5

Tnfsf14

tumor necrosis factor (ligand) superfamily, member 14

HVEM-L, HVEML, LIGHT, LTg, Ly113, Tnlg1d, tumor necrosis factor ligand superfamily member 14, tumor necrosis factor ligand 1d

Tumor necrosis factor ligand superfamily member 14

LIGHT/TNFSF14 protein (CD258; TNFRSF14) is a type II transmembrane protein produced by activated T cells. It is a TNFRSF14/HVEM ligand and belongs to the tumor necrosis factor (TNF) family. LIGHT/TNFSF14 is mainly expressed in spleen, with two subtypes: membrane-bound type and soluble type [1]. LIGHT/TNFSF14 protein can be used as immune checkpoint molecule of tumor, and stimulate natural killer cells to produce interferon TFNgamma, triggering tumor apoptosis signal [2]. LIGHT/TNFSF14 is also involved in the dominant LTbetaR-NIK-p52 NF-kappaB pathway promoting the expression of inflammatory gene[3]. In addition, LIGHT/TNFSF14 protein is a co-stimulatory factor that activates lymphoid cells and has an inhibitory effect on herpes virus infection[4]. Mouse LIGHT/TNFSF14 Protein has 239 amino acids and a transmembrane domain (38-58 a.a.). LIGHT/TNFSF14 Protein, Mouse (sf9, His, solution) is the extracellular part (D72-V239) of mouse LIGHT/TNFSF14 Protein in solution form, produced by Sf9 insect cells, with N-terminal His-tag.

-80°C

41116100

Mouse