Lipoprotein, Low Density, Oxidized

Athens Research

Lipoprotein, Low Density, Oxidized

9

Cell Culture Media, In Vitro Diagnostics, Assay Development, Cardiovascular Disease, Diabetes, Inflammation, Oxidative Stress

Research Use Only

≥ 95% by electrophoresis

Oxidized low-density lipoprotein (Ox-LDL) is a modified form of LDL in which both the lipid and protein components, particularly apolipoprotein B-100, undergo oxidative changes. These modifications include the formation of aldehydes, cross-linking of amino acids, and the generation of new antigenic epitopes, making Ox-LDL structurally and functionally distinct from native LDL. Functionally, Ox-LDL is recognized and taken up by macrophage scavenger receptors, leading to foam cell formation-a key step in atherogenesis. Ox-LDL also acts as a cytotoxin, injuring endothelial cells, increasing endothelial permeability, and promoting inflammatory responses, which further contribute to vascular dysfunction and lesion development. Clinically, elevated levels of Ox-LDL are strongly associated with atherosclerosis, metabolic syndrome, type 2 diabetes, and coronary heart disease. Ox-LDL is implicated in the progression of these diseases due to its pro-inflammatory and cytotoxic effects on vascular cells. In research and diagnostics, Ox-LDL is used to study cellular responses to oxidative stress, to assess cardiovascular risk, and as a probe in assays such as ELISA, Western blot, and fluorescence microscopy to track its uptake and effects in biological systems.

more then 6 months from the production date

Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

+2 - 8° C

12352202