Lipoproteins, High Density
12-16-080412
Product group Proteins / Signaling Molecules
Overview
- SupplierAthens Research
- Product NameLipoproteins, High Density
- Delivery Days Customer9
- Applications SupplierCell Culture Media, In Vitro Diagnostics, Assay Development, Cardiovascular Disease
- CertificationResearch Use Only
- Estimated Purity≥ 95% by electrophoresis
- Scientific DescriptionHigh-density lipoprotein (HDL) is a crucial plasma lipoprotein, present at concentrations of 1.0–2.0 g/L in healthy fasting individuals. HDL plays a central role in reverse cholesterol transport, a process in which it collects excess cholesterol from peripheral tissues and transports it back to the liver for excretion or recycling. This function helps maintain cellular cholesterol balance and prevents the buildup of cholesterol in blood vessel walls. HDL also facilitates cholesterol esterification, converting free cholesterol into cholesteryl esters for safe transport in the bloodstream. Beyond lipid transport, HDL exhibits anti-inflammatory, antioxidant, and antithrombotic properties, contributing to vascular health. Clinically, higher HDL levels are strongly associated with a reduced risk of coronary heart disease and atherosclerosis, making it a key biomarker in cardiovascular risk assessment. Therapeutic strategies aimed at raising HDL or enhancing its function are under investigation, with the goal of reducing cardiovascular events and improving long-term heart health.
- Shelf life instructionmore then 1 year from production date
- SourcePrepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.
- Storage Instruction+2 - 8° C
- UNSPSC12352202
References
- Liu, C. C., et al., (2022), 'Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function', Nature Neuroscience. 25: pp 1020–1033Read this paper
- Zhong, C. C., et al., (2018), 'Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species', Acta Pharmacologica Sinica 39: pp 1048–1063Read this paper
- Zhang, C., et al., (2019), 'von Willebrand factor self-association is regulated by the shear-dependent unfolding of the A2 domain', Blood Adv 3(7): pp 957–968Read this paper
- Tarlton, J. M. R., et al., (2021), 'Protection against Glucolipotoxicity by High Density Lipoprotein in Human PANC-1 Hybrid 1.1B4 Pancreatic Beta Cells: The Role of microRNA', Biology 10: pp 218.Read this paper
- Bassila, C., et al., (2024), 'Ligand-dependent interactions between SR-B1 and S1PR1 in macrophages and atherosclerotic plaques', J. Lipid Res. 65(5): pp 100541.Read this paper