Lipoproteins, Intermediate Density

Athens Research

Lipoproteins, Intermediate Density

9

Cardiovascular Disease

Research Use Only

≥ 95% by electrophoresis

Intermediate-density lipoprotein (IDL) is a key component of the endogenous lipid transport system, formed as a metabolic product when very low-density lipoprotein (VLDL) is hydrolyzed by lipoprotein lipase in peripheral tissues. IDL particles are enriched in both triglycerides and cholesterol esters and contain apolipoproteins B-100 and E, which are crucial for their structural integrity and for mediating interactions with cellular receptors. Through the action of cholesteryl ester transfer protein (CETP), IDL acquires additional cholesteryl esters from high-density lipoprotein (HDL), and further processing by hepatic lipase converts IDL into cholesteryl ester-rich low-density lipoprotein (LDL). Functionally, IDL plays a significant role in cholesterol delivery and lipid metabolism. Elevated IDL levels are independently associated with the progression of carotid atherosclerosis, ischemic heart disease, and stroke, with some evidence suggesting IDL may be even more atherogenic than LDL. Clinically, IDL measurement is gaining attention as a novel risk factor for cardiovascular disease and is used in research to better understand atherogenesis and lipid metabolism.

more then 6 months from the production date

Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

+2 - 8° C

12352202