Lipoproteins, Low Density, Tissue Culture Grade

Athens Research

Lipoproteins, Low Density, Tissue Culture Grade

9

Cell Culture Media, In Vitro Diagnostics, Assay Development, Cardiovascular Disease

Research Use Only

Single arc by IEP against antisera to whole human serum. Essentially free of other plasma lipoproteins as determined by electrophoresis using a SPIFE Vis Cholesterol gel kit for lipids and Coomassie Blue for proteins.

Low-density lipoprotein (LDL) is a major plasma lipoprotein, with normal fasting concentrations ranging from 2.0 to 3.5 g/L, and accounts for about 50% of the total lipoprotein mass in the bloodstream. LDL’s primary role is to transport cholesterol and cholesteryl esters from the liver to peripheral tissues, where cholesterol is essential for membrane structure and steroid hormone synthesis. The protein component, apolipoprotein B-100, enables LDL to bind to LDL receptors on cell surfaces, facilitating cholesterol uptake via receptor-mediated endocytosis. Elevated LDL levels are a well-established risk factor for atherosclerosis and coronary heart disease, as excess LDL cholesterol can accumulate in arterial walls, triggering inflammation and plaque formation. LDL is also implicated in other conditions such as stroke and peripheral artery disease. Clinically, LDL measurement is central to cardiovascular risk assessment and guides therapeutic interventions. In research, LDL is used to study lipid metabolism, receptor interactions, and the development of lipid-lowering drugs.

Open under a laminar flow hood; ≤ 7 days once opened

Prepared from fresh, non-frozen plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA-required tests.

+2 - 8° C

12352202