Lirafugratinib (hydrochloride) [2688040-45-9]
HY-147250A
CAS Number2688040-45-9
Product group Chemicals
Estimated Purity98.96
Molecular Weight546.00
Overview
- SupplierMedChem Express
- Product NameLirafugratinib (hydrochloride) [2688040-45-9]
- Delivery Days Customer10
- CAS Number2688040-45-9
- CertificationResearch Use Only
- Estimated Purity98.96
- Molecular FormulaC28H25ClFN7O2
- Molecular Weight546.00
- Scientific DescriptionLirafugratinib (RLY-4008) hydrochloride is an orally active, irreversible and highly selective FGFR2 inhibitor with an IC50 of 3 nM. Lirafugratinib hydrochloride covalently binds to Cys491. Lirafugratinib hydrochloride targets FGFR2 primary alterations and resistance mutations and induces tumor regression while sparing other FGFRs[1].
- SMILESO=C(C(C)=C)NC1=CC=C(C2=C(C3=C(N)N=CN=C3N2C)C4=CC(F)=C(OC5=NC=CC(C)=N5)C=C4)C=C1.Cl
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12131703