Lithocholic acid 3-sulfate (disodium) [64936-81-8]

MedChem Express

Lithocholic acid 3-sulfate (disodium) [64936-81-8]

10

64936-81-8

Research Use Only

99.93

C24H38Na2O6S

500.60

Lithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 41 and 42.4 (absence of Zn2+) and 0.88 and 0.97 microM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Lithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Lithocholic acid 3-sulfate disodium can be used for the research of gallbladder disease[1].

C[C@]1(CC2)[C@](CC[C@]1([H])[C@H](C)CCC(O[Na])=O)([H])[C@@](CC[C@]3([H])C[C@@H]4O[S](=O)(O[Na])=O)([H])[C@@]2([H])[C@]3(CC4)C

-20°C

12352200