LJI308

MedChem Express

LJI308 [1627709-94-7]

10

1627709-94-7

Research Use Only

99.07

C21H18F2N2O2

368.38

LJI308 is a potent pan- ribosomal S6 kinase (RSK) inhibitor, with IC 50 s of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. LJI308 inhibits the phosphorylation of RSK (T359/S363) and YB-1 (S102) after irradiation, treatment with EGF, and in cells expressing a KRAS mutation [1] [2] .

OC1=C(C=C(C=C1F)C2=C(C=CN=C2)C3=CC=C(C=C3)N4CCOCC4)F

-20°C,2°C to 8°C

12352200