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LJI308

HY-19713
MedChem Express
CAS Number1627709-94-7
Product group Chemicals
Estimated Purity99.07
Molecular Weight368.38
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Overview

  • Supplier
    MedChem Express
  • Product Name
    LJI308 [1627709-94-7]
  • Delivery Days Customer
    10
  • CAS Number
    1627709-94-7
  • Certification
    Research Use Only
  • Estimated Purity
    99.07
  • Molecular Formula
    C21H18F2N2O2
  • Molecular Weight
    368.38
  • Scientific Description
    LJI308 is a potent pan-ribosomal S6 kinase (RSK) inhibitor, with IC50s of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. LJI308 inhibits the phosphorylation of RSK (T359/S363) and YB-1 (S102) after irradiation, treatment with EGF, and in cells expressing a KRAS mutation[1][2].
  • SMILES
    OC1=C(C=C(C=C1F)C2=C(C=CN=C2)C3=CC=C(C=C3)N4CCOCC4)F
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

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